Selected publications:

Multiplexed in vivo base editing defines functional gene-variant-context interactions | pdf

Computational modeling of human genetic variants in mice | pdf

Prime editing sensors enable multiplexed genome editing | pdf

High throughput evaluation of genetic variants with prime editing sensor libraries | pdf | PEGG Tool | MIT News | HHMI News | Ludwig Link | TheScientist | Technology Networks

A prime editor mouse to model a broad spectrum of somatic mutations in vivo | pdf

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants | pdf | BE-SCAN

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 | pdf

Phase and context shape the function of composite oncogenic mutations | pdf

Rapid modelling of cooperating genetic events in cancer through somatic genome editing | pdf

All publications

Annotation key:

Ψ Supervised Ph.D. student

Ω Supervised postdoctoral researcher

λ Supervised research technician

π Supervised undergraduate or visiting student

* Co-1st authorship (equal contribution)

§ Other equal contribution

# Co-corresponding author

  1. Ye, Z., Khademi, A. §, Barbosa, R. L. §, Birnbaum, F., Brown, M. R., Fowler, C. E., Arroyo-Ortega, A., Lee, D., Feng, L., Gates, L. A., Patriotis, A. L., Keating, A. E., Sánchez-Rivera, F. J.#, and Soto-Feliciano, Y. M.# (2026). Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate. bioRxiv. doi: https://doi.org/10.64898/2026.04.14.718582. In review.

  2. Wang, N. B., Blanch-Asensio, A., Cevasco, H.Ψ, Ploessl, D. S., Gumustop, D. R., Ehmann, M. E., Castellanos, M. F., Sánchez-Rivera, F. J., O'Shea, T. M., and Galloway, K. E. (2026). Programmable nanobody circuits for cell selection. bioRxiv. doi: 10.64898/2026.02.22.707289. In revision.

  3. Torborg, S. R., Kim, J. Y., Singhal, A., Grbovic-Huezo, O., Holm, M., Wu, K., Han, X., Ho, Y. J., Haglund, C., Mitchell, M. J., Lowe, S. W., Dow, L. E., Pitter, K. L., Sánchez-Rivera, F. J., Levchenko, A., and Tammela, T. (2026). Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Developmental Cell. doi: 10.1016/j.devcel.2026.02.017.

  4. Fröse, J., Chen, E.Ψ, Whittaker, C. A., Leclerc, P., Doherty, S., Langenbucher, A., Shao, J., Hellinger, R. D., Goulet, D., Tammela, T., Sánchez-Rivera, F. J., and Hemann, M. T. (2026). Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer. bioRxiv. doi: 10.1101/2025.07.24.666408. In review.

  5. Detrés, D.Ψ, Sánchez-Rivera, F. J. (2026). A SLiM view of the human proteome. Nature Structural & Molecular Biology. doi: 10.1038/s41594-026-01770-2.

  6. Jain, N., Shi, Y., May, C., Mitra, S., Bucher, P., Dobrin, A., Zhao, Z., Hanina, S., Rajasekhar, V. K., Yao, Y., Mansilla-Soto, J., Leibold, J., Leslie, C. S., Sánchez-Rivera, F. J., Feucht, J., and Sadelain, M. (2026). Integrated chronic in vivo and in vitro screens uncover NFIL3 as a driver of T cell dysfunction. Cancer Discovery. doi: 10.1158/2159-8290.CD-25-1524.

  7. Bossowski, J. P., Pillai, R., Kilian, J., Wong Lau, A., Nakamura, M., Rashidfarrokhi, A., Hao, Y., Li, R., Wu, K., Hattori, T., Glasser, E., Koide, A., Wang, L., Moreira, A. L., Hajdu, C., Rajalingam, S., LeBoeuf, S. E., Le, H., Lee, S., Oh, J. W., Joe, C., Kim, H., Ock, C. Y., Lee, S. H., Wang, H., Patel, A. A. H., Sayin, V. I., Tsirigos, A., Wong, K. K., Koralov, S. B., Pende, M., Sánchez-Rivera, F. J., Simeone, D. M., Zervantonakis, I. K., Koide, S.#, and Papagiannakopoulos, T.# (2026). The integrated stress response promotes immune evasion through Lipocalin 2. Nature. doi: 10.1038/s41586-026-10143-0.

  8. Halim, S.*, Sebastian, R. M.*, Liivak, K. E., Patrick, J. E., Hui, T., Amici, D. R., Giacomelli, A. O., Ríos, P., Butty, V. L., Hahn, W. C., Sánchez-Rivera, F. J., Mendillo, M. L., Lin, Y. S., and Shoulders, M. D. (2026). Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network. Molecular Cell. doi: 10.1016/j.molcel.2025.12.013.

  9. Efe, G., Cunningham, K., Rustgi, A. K., Prives, C., Manfredi, J. J., Sánchez-Rivera, F. J. (2026). Mutant p53: evolving perspectives. Genes & Development. doi: 10.1101/gad.353408.125.

  10. Abbott, K. L.*, Subudhi, S.*, Ferreira, R.*, Gültekin, Y., Steinbuch, S. C., Munim, M. B., Ramesh, D. L., Honeder, S. E., Kumar, A. S., Wu, M., Hansen, J. A., Shevzov-Zebrun, A., Rashan, E. H., Eghbalian, K. M., Sivanand, S., Barbeau, A. M., Riedmayr, L. M., Duquette, M., Ali, A., Henning, N., Trojan, S. E., Waite, M., Kunchok, T., Nakano, M. A., Gourgue, F., Ferraro, G. B., Do, B. T., Spanoudaki, V., Sánchez-Rivera, F. J., Jin, X., Church, G. M.#, Jain, R. K.#, Vander Heiden, M. G.# (2026). Nutrient requirements of organ-specific metastasis in breast cancer. Nature. doi: 10.1038/s41586-025-09898-9.

  11. Gould, S. I.Ψ, Acosta, J.Ω, Boscolo Bielo, L., Jaboldinov, A.π, Johnson, G. A.Ψ, Contreras, M. E.Ψ, Wuest, A. N.λ, Bremont, E.λ, Toure, M. A., Xiang, Y., Kozicka, Z., Hemann, M. T., Koehler, A. N., Chandarlapaty, S., Sánchez-Rivera, F. J. (2025). A functional map of CDK-drug interactions at single amino acid resolution. bioRxiv. doi: 10.1101/2025.11.02.685764. In revision.

  12. Roth, J. F.Ω, Chen, E.*Ψ, Cevasco, H.*Ψ, Sánchez-Rivera, F. J. (2025). Engineering Cancer with Next-Generation Genome Editing Tools. Annual Review of Cancer Biology. 10:135-156. doi: 10.1146/annurev-cancerbio-070824-123431.

  13. Bucher, P., Brückner, N. §, Kortendieck, J. §, Grimm, M., Schleicher, J. T., Bartels, K., Hardy, S., Rausch, M., Wurzer, H., Thiemann, M., May, C., Mitstorfer, M., Letzgus, D., Quach, J., Schneider, C., Ispan, D. A., Gonzalez-Menendez, I., Jain, N., Ho, Y. J., Chen, J., Sánchez-Rivera, F. J., Sun, J., Quintanilla-Martinez, L., Trautwein, C., Weigelin, B., Claassen, M., Sadelain, M., Feucht, J.#, and Leibold, J.# (2026). CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency. Nature Cancer. doi: 10.1038/s43018-025-01099-7.

  14. Dong, K.Ψ, Gould, S. I.Ψ, Li, M., Sánchez-Rivera, F. J. (2025). Computational modeling of human genetic variants in mice. Nature Biotechnology. doi: 10.1038/s41587-025-02925-0.

  15. Wuest, A. N.λ, Parikh, J.λ, Sánchez-Rivera, F. J. (2025). Next-generation precision cancer mouse models. Lab Animal. In press.

  16. Lagan, E.*, Gannon, D.*, Silva, A. J.§, Bibawi, P.§, Doherty, A., Nimmo, D., McCole, R., Monger, C., Genesi, G. L., Vanderlinden, A., Innes, J. A., Jones, C. L. E., Yang, L., Chen, B., van Mierlo, G., Jansen, P. W. T. C., Pednekar, C., Von Kriegsheim, A., Wynne, K., Sánchez-Rivera, F. J., Soto-Feliciano, Y. M., Carcaboso, A. M., Vermeulen, M., Oliviero, G., Chen, C., Phillips, R. E.#, Bracken, A. P.#, Brien, G. L.# (2025). Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma. Molecular Cell. doi: 10.1016/j.molcel.2025.04.026.

  17. Wu, K.Ψ, Sánchez-Rivera, F. J. (2025). It's prime time for multiplexed prime editing. Cell Genomics. doi: 10.1016/j.xgen.2025.100852.

  18. Acosta, J.*Ω, Johnson, G. A.*Ψ, Gould, S. I.*Ψ, Dong, K.π, Lendner, Y., Detrés, D.Ψ, Atwa, O.Ψ, Bulkens, J.π, Gruber, S., Contreras, M. E.Ψ, Narendra, V. K., Hemann, M. T.#, Sánchez-Rivera, F. J.# (2025). Multiplexed in vivo base editing defines functional gene-variant-context interactions. bioRxiv. doi: 10.1101/2025.02.23.639770.

  19. Gould, S. I.Ψ, Sánchez-Rivera, F. J. (2025). Using Prime Editing Guide Generator (PEGG) for high-throughput generation of prime editing sensor libraries. Methods in Molecular Biology. doi: 10.1016/bs.mie.2025.01.006.

  20. Perr, J., Langen, A., Almahayni, K., Nestola, G., Chai, P., Lebedenko, C. G., Volk, R., Detrés, D.Ψ, Caldwell, R. M., Spiekermann, M., Hemberger, H., Bisaria, N., Aiba, T., Sánchez-Rivera, F. J., Tzelepis, K., Calo, E., Möckl, L., Zaro, B., Flynn, R. A. (2025). RNA binding proteins and glycoRNAs form domains on the cell surface for cell penetrating peptide entry. Cell. doi: 10.1016/j.cell.2025.01.040.

  21. Schmidt, H.*, Zhang, M.*, Chakarov, D., Bansal, V., Mourelatos, H., Sánchez-Rivera, F. J., Lowe, S. W., Ventura, A.#, Leslie, C. S.#, Pritykin, Y.# (2025). Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2. Genome Biology. 26, 41. doi: 10.1186/s13059-025-03488-8.

  22. Zucker, M.*, Perry, M. A.*, Gould, S. I.Ψ, Elkrief, A., Safonov, A., Thummalapalli, R., Mehine, M., Chakravarty, D., Brannon, A. R., Ladanyi, M., Razavi, P., Donoghue, M. T. A., Murciano-Goroff, Y. R., Grigoriadis, K., McGranahan, N., Jamal-Hanjani, M., Swanton, C., Chen, Y., Shen, R., Chandarlapaty, S., Solit, D. B., Schultz, N., Berger, M. F., Chang, J., Schoenfeld, A. J., Sánchez-Rivera, F. J., Reznik, E.#, Bandlamudi, C.# (2025). Pan-cancer analysis of biallelic inactivation patterns in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer. Cell. doi: 10.1016/j.cell.2024.11.010.

  23. Roth, J. F.Ω, Sánchez-Rivera, F. J. (2024). Precision Mutational Scanning: Your Multipass to the Future of Genetics. Nature Methods. doi: 10.1038/s41592-024-02522-0.

  24. Lee, J. H., Sánchez-Rivera, F. J., He, L., Basnet, H., Chen, F., Spina, E., Li, L., Torner, C., Chan, J. E., Yarlagadda, D. V. K., Park, J. S., Sussman, C., Rudin, C. M., Lowe, S. W., Tammela, T., Macias, M. J., Koche, R. P., Massagué, J. (2024). TGF-β and RAS jointly unmask primed enhancers to drive metastasis. Cell. doi: 10.1016/j.cell.2024.08.014.

  25. Le Pen, J.*, Paniccia, G.*, Kinast, V.§, Moncada-Velez, M.§, Ashbrook, A. W.§, Bauer, M.§, Hoffmann, H-H.§, Pinharanda, A.§, Ricardo-Lax, I.§, Stenzel, A. F.§, Rosado-Olivieri, E. A.§, Dinnon, K. H., Doyle, W. C., Freije, C. A., Hong, S-H., Lee, D., Lewy, T., Luna, J. M., Peace, A., Schmidt, C., Schneider, W. M., Winkler, R., Yip, E. Z., Larson, C., McGinn, T., Menezes, M-R., Ramos-Espiritu, L., Banerjee, P., Poirier, J. T., Sánchez-Rivera, F. J., Cobat, A., Zhang, Q., Casanova, J-L., Carroll, T. S., Glickman, F. J., Michailidis, E.#, Razooky, B.#, MacDonald, M. R.#, Rice, C. M.# (2024). A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry. PLoS Biology. doi: 10.1371/journal.pbio.3002767.

  26. Johnson, G. A.Ψ*, Gould, S. I.Ψ*, Sánchez-Rivera, F. J.# (2024). Deconstructing cancer with precision genome editing technologies. Biochemical Society Transactions. doi: 10.1042/BST20230984.

  27. Gould, S. I.Ψ, Wuest, A. N.λ, Dong, K.π, Johnson, G. A.Ψ, Hsu, A., Narendra, V. K., Atwa, O.Ψ, Levine, S. S., Liu, D. R., Sánchez-Rivera, F. J. (2024). High throughput evaluation of genetic variants with prime editing sensor libraries. Nature Biotechnology. doi: 10.1038/s41587-024-02172-9.

  28. Sánchez-Rivera, F. J.#, Dow, L. E.# (2024). How CRISPR is Revolutionizing the Generation of New Models for Cancer Research. Cold Spring Harbor Perspectives in Medicine: Advances in modeling cancer in mice. 14(5):a041384. doi: 10.1101/cshperspect.a041384.

  29. Karagiannis, D., Wu, W., Li, A., Hayashi, M., Chen, X., Yip, M., Mangipudy, V., Xu, X., Sánchez-Rivera, F. J., Soto-Feliciano, Y. M., Ye, J., Papagiannakopoulos, T., Lu, C. (2023). Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors. Cell Reports. 30;43(1):113629.

  30. Katti, A., Vega-Pérez, A., Foronda, M., Zimmermann, J., Paz Zafra, M., Granowsky, E., Goswami, S., Gardner, E., Diaz, B., Simon, J., Wuest, A.λ, Luan, W., Calvo Fernandez, M. T., Kadina, A., Walker, J., Holden, K., Lowe, S. W., Sánchez-Rivera, F. J., Dow, L. E. (2023). Rapid generation of precision preclinical cancer models using regulatable in vivo base editing. Nature Biotechnology. doi: 10.1038/s41587-023-01900-x.

  31. Chen, X., Li, Y., Zhu, F., Xu, X., Estrella, B., Pazos, M. A., McGuire, J. T., Karagiannis, D., Sahu, V., Mustafokulov, M., Scuoppo, C., Sánchez-Rivera, F. J., Soto-Feliciano, Y. M., Pasqualucci, L., Ciccia, A., Amengual, J. E., Lu, C. (2023). Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Nature Communications. 14, 4259.

  32. Ely, Z. A.*, Mathey-Andrews, N.*, Naranjo, S., Gould, S. I.Ψ, Cabana, C. M., Mercer, K. L., Rideout III, W. M., Newby, G. A., Cervantes Jaramillo, G., Holland, K., Randolph, P. B., Freed-Pastor, W. A., Davis, J. R., Westcott, P. M. K., Anzalone, A. V., Pattada, N. B., Sánchez-Rivera, F. J., Liu, D. R., Jacks, T. (2023). A prime editor mouse for modeling a broad spectrum of somatic mutations in vivo. Nature Biotechnology. doi: 10.1038/s41587-023-01783-y.

  33. Hu, J., Sánchez-Rivera, F. J., Johnson, G., Wang, Z., Ho, Y., Ganesh, K., Gan, S., Hampton, J., Zhao, H., Kottapalli, S., de Stanchina, E., Iacobuzio-Donahue, C. A., Pe'er, D., Lowe, S. W., Sun, J., Massagué, J. (2023). STING suppresses the reactivation of dormant metastasis. Nature. 616, 806–813.

  34. Soto-Feliciano, Y. M.*, Sánchez-Rivera, F. J.*, Perner, F.*, Barrows, D., Kastenhuber, E. R., Ho, Y., Carroll, T., Xiong, J., Soshnev, A., Gates, L., Beytagh, M. C., Cheon, D., Gu, S., Liu, X. S., Krivtsov, A. V., Meneses, M., de Stanchina, E., Armstrong, S. A.#, Lowe, S. W.#, Allis, C. D.# (2023). A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Cancer Discovery. doi: 10.1158/2159-8290.CD-22-0416.

  35. Benabdallah, N., Dalal, V., Scott, R. W., Marcous, F., Sotiriou, A., Kommoss, F., Pejkovska, A., Gaspar, L., Wagner, L., Sánchez-Rivera, F. J., Ta, M., Thornton, S., Nielsen, T., Underhill, T., Banito, A. (2023). Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability. Nature Structural & Molecular Biology.

  36. Leibold, J.*#, Amor, C.*, Tsanov, K. M.*, Ho, Y., Sánchez-Rivera, F. J., Feucht, J., Baslan, T., Chen, H., Tian, S., Simon, J., Wuest, A., Wilkinson, J. E., Lowe, S. W.# (2023). Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nature Cancer.

  37. Sánchez-Rivera, F. J.*, Díaz, B. J.*, Kastenhuber, E. R.*, Schmidt, H., Katti, A., Kennedy, M., Tem, V., Ho, Y., Leibold, J., Paffenholz, S. V., Barriga, F. M., Chu, K., Goswami, S., Wuest, A. N., Simon, J. M., Tsanov, K. M., Chakravarty, D., Zhang, H., Leslie, C. S., Lowe, S. W., Dow, L. E. (2022). Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nature Biotechnology. 40, 862–873.

  38. Li, X.*, Huang, C.*, Sánchez-Rivera, F. J., Kennedy, M., Tschaharganeh, D. F., Morris IV, J. P., Montinaro, A., O'Rourke, K. P., Banito, A., Wilkinson, J. E., Chen, C., Ho, Y., Dow, L. E., Tian, S., Luan, W., de Stanchina, E., Zhang, T., Gray, N. S., Walczak, H., Lowe, S. W. (2022). A preclinical platform for assessing anti-tumor effects and systemic toxicities of cancer drug targets. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.2110557119.

  39. Gearty, S. V., Dündar, F., Zumbo, P., Espinosa-Carrasco, G., Shakiba, M., Sánchez-Rivera, F. J., Socci, N. D., Trivedi, P., Lowe, S. W., Lauer, P., Mohibullah, N., Viale, A., DiLorenzo, T. P., Betel, D., Schietinger, A. (2021). A stem-like CD8 T cell population initiates and sustains beta cell destruction in type 1 diabetes. Nature. 602, 156–161.

  40. Shakiba, M., Zumbo, P., Espinosa-Carrasco, G., Menocal, L., Dündar, F., Carson, S. E., Bruno, E. M., Sánchez-Rivera, F. J., Lowe, S. W., Camara, S., Koche, R. P., Reuter, V. P., Socci, N. D., Whitlock, B., Tamzalit, F., Huse, M., Hellmann, M. D., Wells, D. K., Defranoux, N. A., Betel, D., Philip, M., Schietinger, A. (2021). TCR affinity dictates T cell functional states in tumors. Journal of Experimental Medicine. doi: 10.1084/jem.20201966.

  41. Ricardo-Lax, I.*, Luna, J. M.*, Thao, T. T. N., Le Pen, J., Yu, Y., Hoffmann, H. H., Schneider, W. M., Fernandez-Martinez, J., Schmidt, F., Weisblum, Y., Trüeb, B. S., Veiga, I. B., Schmied, K., Ebert, N., Michailidis, E., Razooky, B. S., Peace, A., Sánchez-Rivera, F. J., Lowe, S. W., Rout, M. P., Hatziioannou, T., Bieniasz, P. D., Poirier, J. T., MacDonald, M. R., Thiel, V.#, Rice, C. M.# (2021). Replication and single-cycle delivery of SARS-CoV-2 replicons. Science. 374, 1099–1106.

  42. Concepcion, C. P., Ma, S.*, LaFave, L. M.*, Bhutkar, A.*, Liu, M., DeAngelo, L. P., Kim, J. Y., Del Priore, I., Schoenfeld, A. J., Miller, M., Kartha, V. K., Westcott, P. M. K., Sánchez-Rivera, F. J., Meli, K., Gupta, M., Bronson, R. T., Riely, G. J., Rekhtman, N., Rudin, C. M., Kim, C. F., Regev, A., Buenrostro, J. D., Jacks, T. (2021). Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. Cancer Discovery. doi: 10.1158/2159-8290.CD-21-0248.

  43. Ciampricotti, M., Karakousi, T.*, Richards, A. L.*, Quintanal-Villalonga, A., Karatza, A., Caeser, R., Costa, E. A., Allaj, V., Manoj, P., Spainhower, K. B., Kombak, F. E., Sánchez-Rivera, F. J., Jaspers, J., Zavitsanou, A., Maddalo, D., Ventura, A., Rideout III, W. M., Akama-Garren, E. H., Jacks, T., Donoghue, M., Sen, T., Oliver, T. G., Poirier, J. T., Papagiannakopoulos, T.#, Rudin, C. M.# (2021). Rlf-Mycl1 gene fusion drives tumorigenesis and metastasis in a novel mouse model of small cell lung cancer. Cancer Discovery. doi: 10.1158/2159-8290.CD-21-0441.

  44. Sánchez-Rivera, F. J.*, Ryan, J.*, Soto-Feliciano, Y. M., Beytagh, M. C., Xuan, L., Feldser, D. M., Hemann, M. T., Letai, A.#, Jacks, T.# (2021). Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences. 118(23) e2019740118.

  45. Schneider, W. M.*, Luna, J. M.*, Hoffmann, H. H.*, Sánchez-Rivera, F. J.*, Leal, A. A., Ashbrook, A. W., Le Pen, J., Ricardo-Lax, I., Michailidis, E., Peace, A., Stenzel, A. F., Lowe, S. W., MacDonald, M. R., Rice, C. M.#, Poirier, J. T.# (2021). Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks. Cell. 184, 120–132. Cover article.

  46. Hoffmann, H. H.*, Sánchez-Rivera, F. J.*, Schneider, W. M.*, Luna, J. M.*, Soto-Feliciano, Y. M., Ashbrook, A. W., Le Pen, J., Leal, A. A., Ricardo-Lax, I., Michailidis, E., Hao, Y., Stenzel, A. F., Peace, A., Zuber, J., Allis, C. D., Lowe, S. W., MacDonald, M. R., Poirier, J. T.#, Rice, C. M.# (2021). Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Cell Host & Microbe. 29, 1–14.

  47. Jiang, T., Sánchez-Rivera, F. J., Soto-Feliciano, Y. M., Yang, Q., Song, C., Bhutkar, A., Haynes, C. M., Hemann, M. T., Xue, W. (2020). Targeting de novo purine synthesis pathway via ADSL depletion impairs liver cancer growth by perturbing mitochondrial function. Hepatology. 74: 233–247.

  48. Gupta, M., Concepcion, C. P., Fahey, C. G., Fillmore-Brainson, C., Sánchez-Rivera, F. J., Pessina, P., Bhutkar, A., Kim, J. Y., Simoneau, A., Beytagh, M. C., Keshishian, H., Stanclift, C., Schenone, M., Mani, D. R., Li, C., Oh, A., Li, F., Hu, H., Karatza, A., Wong, K. K., Shaw, A. T., Hata, A. N., Carr, S. A., Zou, L., Jacks, T., Kim, C. F. (2020). BRG1 loss predisposes lung cancers to replicative stress and ATR dependency. Cancer Research. 80(18), 3841–3854.

  49. Romero, R.*, Sánchez-Rivera, F. J.*, Westcott, P. M. K., Mercer, K. L., Bhutkar, A., Muir, A., González-Robles, T. J., Lamboy-Rodríguez, S. A., Liao, L. Z., Ng, S. R., Li, L., Colón, C. I., Naranjo, S., Beytagh, M. C., Lewis, C. A., Hsu, P. P., Bronson, R. T., Vander Heiden, M. G., Jacks, T. (2020). Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nature Cancer. 1, 589–602.

  50. Gorelick, A. N., Sánchez-Rivera, F. J., Cai, Y., Bielski, C. M., Biederstedt, E., Jonsson, P., Richards, A. L., Vasan, N., Penson, A. V., Friedman, N. D., Ho, Y., Baslan, T., Bandlamudi, C., Scaltriti, M., Schultz, N., Lowe, S. W., Reznik, E.#, Taylor, B. S.# (2020). Phase and context shape the function of composite oncogenic mutations. Nature. 582, 100–103.

  51. Oni, T. E.*, Biffi, G.*, Baker, L. A., Hao, Y., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C., Sánchez-Rivera, F. J., Cox, H., Brosnan, E., Doshi, A., Lumia, R. P., Khaledi, K., Park, Y., Trotman, L. C., Lowe, S. W., Krasnitz, A., Vakoc, C. R., Tuveson, D. A. (2020). SOAT1 abrogates cholesterol feedback inhibition to promote mevalonate pathway dependency in pancreatic cancer. Journal of Experimental Medicine. 217(9): e20192389.

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